Oxidative stress and immune thrombocytopenia PY2013 IR95 教材 Glutathione, Stanford university

Oxidative stress and immune thrombocytopenia PY2013 IR95 教材 Glutathione, Stanford university

##

Oxidative stress and immune thrombocytopenia

Bing Zhang et al. Semin Hematol. 2013 Jul.

Free article

Hide details

Semin Hematol

. 2013 Jul;50(3):e1-4.

doi: 10.1053/j.seminhematol.2013.06.011.

Authors

Bing Zhang 1, James L Zehnder

Affiliation

1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

PMID: 23953344

DOI: 10.1053/j.seminhematol.2013.06.011

Full text links

Cite

Linked Discoveries

Abstract

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased platelet destruction or decreased platelet production. The mechanism of the disease has been extensively studied so that we now have a much improved understanding of the pathophysiology; however, the trigger of the autoimmunity remains unclear. More recently, oxidative stress was identified to be involved in the pathogenesis of ITP and provides a new hypothesis for the initiation of autoimmunity in patients with ITP. In this review, oxidative stress and its impact on autoimmunity, particularly ITP, will be covered.