Glutathione-degrading enzymes in the complex landscape of tumors PY2024 IR95 教材 Glutathione-degrading enzymes in the complex landscape of tumors PY2024 IR95 教材 ## Glutathione-degrading enzymes in the complex landscape of tumors Tianyi Zhang, Chongjie Yao, Xu Zhou, Shimin Liu, Li Qi, Shiguo Zhu, Chen Zhao, Dan Hu, Weidong Shen International Journal of Oncology 65 (1), 72, 2024 Glutathione (GSH)-degrading enzymes are essential for starting the first stages of GSH degradation. These enzymes include extracellular γ-glutamyl transpeptidase (GGT) and intracellular GSH-specific γ-glutamylcyclotransferase 1 (ChaC1) and 2. These enzymes are essential for cellular activities, such as immune response, differentiation, proliferation, homeostasis regulation and programmed cell death. Tumor tissue frequently exhibits abnormal expression of GSH-degrading enzymes, which has a key impact on the development and spread of malignancies. The present review summarizes gene and protein structure, catal...